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NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE Thyroid Troubles: A Case Study in Negative Feedback Regulation by Breanna N. Harris Department of...
National Center for Case Study Teaching in Science
, University at Buf
alo, State University oF New York.
Originally published September 19, 2016. Please see our
, which outline our policy concerning permissible reproduction oF this
work. Licensed image in title block Â© mayaÂ±Â²Â²8|Â³otolia, ID 77061020.
Part I â€“ Initial Of
You are six months into a year-long internship at Â´r. Mara Siddiquiâ€™s endocrinology clinic. So Far, youâ€™ve had a great
experience with Â´r. Siddiqui and youâ€™ve seen patients with a wide range oF endocrine issues. Today, you will shadow
Â´r. Siddiqui as she examines Angela Barber, a patient who was reFerred by her primary care physician. While waiting,
you pull up Angelaâ€™s inFormation on the computer and you Âµ
nd that she is a 5Â±-year-old AFrican American woman.
Except For not Feeling like herselF over the last three months, she has no health issues.
Angela arrives at the clinic and you accompany the nurse to the exam room to get Angelaâ€™s vitals. Â´r. Siddiqui comes
into the exam room and asks Angela what has been bothering her. Angela tells the doctor that she has been cold, tired,
Fatigued, and just not Feeling up to her normal activities. She has also gained roughly Â±Â² pounds, even though she has
been consciously monitoring her Food intake. Angela canâ€™t understand what is wrongâ€”she went through menopause a
year ago but she insists that the way she is Feeling is not related to that change; she also has not changed anything else
about her normal routine. Â´r. Siddiqui listens to Angela and then examines her ears, eyes, and throat; she also listens
to Angelaâ€™s lungs and heart, and palpates her neck and abdomen. All oF Angelaâ€™s vitals and the outcome oF the initial
exam are within normal range. Â´r. Siddiqui tells Angela that she suspects a thyroid issue and would like to order some
Angela asks about the thyroid and why it is important. Â´r. Siddiqui asks you to help explain this hormone system to
Â¶. Â´iagram the hypothalamic-pituitary-thyroid axis. Make sure to include the Feedback loops and spell out the
Â±. What is the physiological role oF thyroid hormones? Â´oes T
play a larger role on the target tissues?
Breanna N. Harris
Department oF Biological Sciences
Texas Tech University, Lubbock, TX
A Case Study in Negative
NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE.
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